Idea Details

Team and Contact Details

SNo Student Name School Degree Year Email
1Tahreem ZaheerASABMS/M.PhilFirsttahreem_zaheer@yahoo.com
2Muhammad ShehrozASABMS/M.PhilFirstlio_khan16@yahoo.com
3Quratulain ASABMS/M.PhilFirstquratulainfarooq93@gmail.com
4Azikah JasperASABMS/M.PhilFirstazikahjasper@yahoo.com
5Hamza Arshad DarASABMS/M.PhilFirstdarhamza000@gmail.com

Inter School Idea ? No
Do you need expertises from another area: No
If Yes please provide details of expertises you need:

Idea Details

Idea Name: Flaviviral Vaccine
Slogan: You can't harm me
Startup Domain: Good healh & well-being
Abstract:
    Flaviviruses such as Dengue virus, Zika virus and yellow fever virus are causing a number of diseases worldwide. To combat this problem need of hour is to design a cost effective broadspectrum vaccine
What is the unmet need in society that your idea will fulfill ?
    Presently there is no vaccine available that can elicit a broad-spectrum immune response against Flaviviruses. Antibodies of Zika virus are also reported in some suspects while Dengue virus is a major concern of Asian countries. A cost-effective strategy is required to fight these pathogens.
Who needs it ? How many would benefit ?
   Flaviviral infections are a global issue. Millions of cases are reported worldwide, but there is no FDA approved vaccine that can help the body to fight these pathogens. A vaccine that can prepare the body to fight against mosquito-borne Flaviviruses is required to fight infection.
How will the solution works
    The aim of the study is to design an insilico based vaccine construct. Reverse vaccinology is a widely used approach to predict putative therapeutic targets. Consensus polyprotein sequence of Flaviviral vaccine would be used to predict CD8 and CD4 based T cell epitopes. The interaction between predicted epitopes and HLA alleles would be helpful in determining the efficacy of this vaccine.Peptide formed after the fusion of these epitopes can elicit broadspectrum humoral and cell-mediated response
Who are your competitors ? How is your solution different
    Pharmaceutical companies that are making anti-viral drugs are our major competitors. Antiviral drugs are used after infection, however, our aim is to make the body immune against future Flaviviral infection. Prophylactic vaccines have proved their efficacy in case of polioviruses.
Status: Approved
Entry Date & Time: 2017-11-30 (0013)